Which clinical feature is part of the DiGeorge syndrome triad?

Which clinical feature is part of the DiGeorge syndrome triad?

• A. Immunodeficiency
• B. Hyperparathyroidism
• C. Hyperglycemia
• D. Osteoporosis

Answer: (A)

Immunodeficiency is part of the DiGeorge triad because the condition is caused by thymic hypoplasia from 22q11.2 deletion, leading to reduced T-cell development and an increased vulnerability to infections. The triad typically includes immune deficiency (thymic aplasia), hypocalcemia from parathyroid hypoplasia, and congenital heart defects. Hyperparathyroidism would cause high calcium and isn’t characteristic here, while hyperglycemia and osteoporosis aren’t defining features of this syndrome.

Immunodeficiency is part of the DiGeorge triad because the condition is caused by thymic hypoplasia from 22q11.2 deletion, leading to reduced T-cell development and an increased vulnerability to infections. The triad typically includes immune deficiency (thymic aplasia), hypocalcemia from parathyroid hypoplasia, and congenital heart defects. Hyperparathyroidism would cause high calcium and isn’t characteristic here, while hyperglycemia and osteoporosis aren’t defining features of this syndrome.